Preheat your oven to 375°F (190°C) and line a baking sheet with parchment paper for easy cleanup.
Prepare the jalapeños: Slice each jalapeño in half lengthwise and remove seeds for less heat or leave some in if you prefer it spicier.
Create the filling: In a mixing bowl, combine softened cream cheese, shredded cheddar cheese, chopped cooked bacon, garlic powder, salt, and pepper. Mix until well blended.
Stuff each jalapeño half: Use a spoon or piping bag to fill each jalapeño half generously with the cheese mixture.
Dip in panko breadcrumbs: Press each filled jalapeño half into panko breadcrumbs until well coated on top for extra crunch.
Bake them: Place stuffed jalapeños on the prepared baking sheet and bake for about 20-25 minutes or until golden brown and bubbly.
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